ROADMAP will foster transitions towards prudent antimicrobial use (AMU) in animal production in a large variety of contexts, by favouring a rethinking antimicrobial decision systems all along the food supply chain. Even if it is possible to learn from successful experiences, there is no "one-size-fits-all" solution to reduce AMU. Various strategies with be necessary to take into account local conditions defined by social, economic, technical and institutional variables. ROADMAP will develop innovative conceptual approaches within a transdisciplinary and multi-actor perspective to engage with animal health professionals, stakeholders and policy-makers. It will adapt, combine and produce tailored strategies to reduce AMU in diverse production systems in Europe and low- and middle-income countries (pig, poultry, cattle and fish sectors).